Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 11/20 | 0.46 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243932 | 0.85 | MPO (0.40) | MPOHAVCR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11224025 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL11231834 | 0.84 | MAPT (0.38) | ALDH1A1MAPTTDP1 | |
| SCHEMBL11228862 | 0.83 | MPO (0.43) | MPOSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL11233166 | 0.83 | RAB9A (0.47) | SMN1; SMN2KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL11232223 | 0.82 | HTT (0.42) | KDM4EALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL11240020 | 0.79 | MAPT (0.42) | MAPTTDP1 | |
| SCHEMBL11237179 | 0.79 | DYRK1A (0.44) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11246747 | 0.75 | TDP1 (0.34) | KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL11238086 | 0.73 | TDP1 (0.47) | ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |