Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230498 | 0.85 | ALDH1A1 (0.53) | ALDH1A1HSD17B10PKMKDM4EGAA | |
| SCHEMBL11224025 | 0.84 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4EPOLBMEN1 | |
| SCHEMBL11231834 | 0.84 | MAPT (0.38) | RAB9AALDH1A1PKMCYP1A2CYP2C19 | |
| SCHEMBL11228862 | 0.83 | MPO (0.43) | ALDH1A1HSD17B10KDM4ECYP1A2CYP2C19 | |
| SCHEMBL11234835 | 0.83 | MPO (0.46) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11232223 | 0.82 | HTT (0.42) | ALDH1A1HSD17B10KDM4EGAAMEN1 | |
| SCHEMBL11240020 | 0.79 | MAPT (0.42) | RAB9APOLBCYP1A2CYP2C19NPSR1 | |
| SCHEMBL11237179 | 0.79 | DYRK1A (0.44) | ALDH1A1HSD17B10KDM4ECASP1CASP7 | |
| SCHEMBL11230744 | 0.77 | RAB9A (0.46) | RAB9AALDH1A1HSD17B10PKMKDM4E | |
| SCHEMBL11246747 | 0.77 | TDP1 (0.34) | ALDH1A1KDM4EDYRK1AMAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |