SCHEMBL7705979

SCHEMBL7705979

CC(=O)Nc1cccc(-c2cc(N)nc(N)c2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
NQO2 P16083 2/20 0.57
NPC1 O15118 5/20 0.57
RAB9A P51151 5/20 0.57
SMN1; SMN2 Q16637 5/20 0.57
TSHR P16473 1/20 0.57
MAP4K4 O95819 1/20 0.56
HSD17B1 P14061 1/20 0.56
HSD17B2 P37059 1/20 0.56
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
MAPK10 P53779 1/20 0.55
FYN P06241 2/20 0.54
USP7 Q93009 1/20 0.54
TP53 P04637 3/20 0.53
MAPT P10636 3/20 0.53
POLB P06746 3/20 0.53
RXFP1 Q9HBX9 1/20 0.53
STAT1 P42224 1/20 0.53
PSMB11 A5LHX3 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11228972 0.83 HSD17B10 (0.57) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL6798003 0.82 ALDH1A1 (0.80) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL7711731 0.82 SMN1; SMN2 (0.66) ALDH1A1NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL4654909 0.81 ALDH1A1 (0.67) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL3786463 0.80 NQO2 (0.73) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL11216528 0.79 CYP17A1 (0.54) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL28742509 0.79 HSD17B10 (0.66) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL8577619 0.78 SMN1; SMN2 (0.70) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL4189391 0.78 PIP4K2A (0.62) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2
SCHEMBL10663620 0.78 CYP17A1 (0.76) ALDH1A1NQO2NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed