Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A9 | P06702 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326651 | 0.75 | KDM4E (0.35) | KDM4EALDH1A1HPGDCRHBPCRHR2 | |
| SCHEMBL1123002 | 0.65 | MMP13 (0.33) | KDM4EALDH1A1HPGD | |
| SCHEMBL29174915 | 0.65 | KMT2A (0.40) | — | |
| SCHEMBL17651761 | 0.65 | GSK3B (0.48) | KDM4EHPGD | |
| SCHEMBL4130221 | 0.64 | GLA (0.40) | KDM4EALDH1A1HPGDCRHBPCRHR2 | |
| SCHEMBL29243928 | 0.63 | DPYD (0.33) | KDM4E | |
| SCHEMBL20597742 | 0.62 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDKDM5A | |
| SCHEMBL13834821 | 0.60 | HPGD (0.33) | KDM4EALDH1A1HPGDKDM5A | |
| SCHEMBL15904700 | 0.60 | PSIP1 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL8962620 | 0.59 | RAB9A (0.49) | KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |
| US-6646009-B2 | Use against proliferative disorders including cancer, and as a radioprotective compound for normal cells from ionizing radiation | Temple University — Of Commonwealth System of Higher Education | 2003-11-11 | — | — | US | disclosed |