Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | WNT3A | P56704 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236432 | 0.84 | PDE3B (0.51) | CYP1A2CYP2C9CYP2C19NPSR1ALDH1A1 | |
| SCHEMBL11241191 | 0.82 | WNT3A (0.45) | MTORWNT3ALRRK2AAK1CYP3A4 | |
| SCHEMBL7273135 | 0.82 | MTOR (0.42) | MTORAAK1 | |
| SCHEMBL11230737 | 0.80 | MTOR (0.40) | MTORAAK1 | |
| SCHEMBL11226168 | 0.77 | ALDH1A1 (0.49) | CYP1A2CYP2C9CYP2C19NPSR1ALDH1A1 | |
| SCHEMBL11396219 | 0.76 | FTO (0.44) | MTORWNT3A | |
| SCHEMBL7270939 | 0.75 | MTOR (0.45) | MTOR | |
| SCHEMBL11236490 | 0.75 | NCOA1 (0.39) | NPSR1MTORALDH1A1CYP3A4 | |
| SCHEMBL11166411 | 0.75 | PIK3CB (0.47) | MTORAAK1 | |
| SCHEMBL11241603 | 0.74 | PDE3B (0.53) | CYP1A2CYP2C9CYP2C19NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |