Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866203 | 0.85 | HRH1 (0.45) | HRH1CYP2A6LMNAMEN1KMT2A | |
| SCHEMBL7330216 | 0.82 | GRM5 (0.42) | GRM5ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL23717535 | 0.81 | GRM5 (0.46) | GRM5ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL30554705 | 0.81 | ALDH1A1 (0.47) | GRM5SLC6A2ALDH1A1L3MBTL1AOC3 | |
| SCHEMBL17778295 | 0.81 | ALDH1A1 (0.47) | GRM5SLC6A2ALDH1A1L3MBTL1AOC3 | |
| SCHEMBL23251404 | 0.77 | GRM5 (0.49) | GRM5ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL10958740 | 0.76 | L3MBTL1 (0.42) | GRM5SLC6A2ALDH1A1L3MBTL1AOC3 | |
| SCHEMBL13696631 | 0.76 | LOX (0.41) | HRH1ALDH1A1L3MBTL1AOC3CYP2A6 | |
| SCHEMBL6508578 | 0.76 | CXCR4 (0.50) | HRH1CYP2A6 | |
| SCHEMBL10150235 | 0.76 | LMNA (0.39) | HRH1CYP2A6LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017679-B1 | PYRIDYLALKYLPYRIMIDONE COMPOUNDS, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-02-24 | — | — | EP | disclosed |
| EP-0017679-A1 | Pyridylalkylpyrimidone compounds, process for preparing them and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-29 | — | — | EP | disclosed |