Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392157 | 0.87 | LMNA (0.40) | LMNACYP2C19ADRB2ADRB1MEN1 | |
| SCHEMBL14260228 | 0.80 | LMNA (0.35) | LMNAADRB2ADRB1NAMPT | |
| SCHEMBL13696631 | 0.78 | LOX (0.41) | CYP2A6HRH1 | |
| SCHEMBL764884 | 0.78 | ADRB2 (0.55) | LMNAADRB2ADRB1 | |
| SCHEMBL764868 | 0.77 | LMNA (0.39) | LMNACYP2A6ADRB2ADRB1MEN1 | |
| SCHEMBL10150889 | 0.76 | CYP2A6 (0.36) | LMNACYP2A6CYP2C19ADRB2ADRB1 | |
| SCHEMBL11233284 | 0.76 | HRH1 (0.44) | LMNACYP2A6MEN1KMT2AHRH1 | |
| SCHEMBL10150236 | 0.74 | LMNA (0.39) | LMNAALOX15CYP2C19ADRB2ADRB1 | |
| SCHEMBL9866203 | 0.74 | HRH1 (0.45) | LMNACYP2A6MEN1KMT2AHSP90AA1 | |
| SCHEMBL20897976 | 0.72 | CHRNB2 (0.48) | LMNACYP2C19ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2008033328-A2 | MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS | TRANZYME PHARMA, INC. (US) | 2008-03-20 | — | — | WO | disclosed |