Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfotep. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfotep SCHEMBL11232718 | 0.98 | MEN1 (0.38) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL461502 | 0.91 | TDP1 (0.39) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL5016573 | 0.88 | MEN1 (0.38) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL1163901 | 0.86 | FFAR3 (0.46) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL7762968 | 0.86 | FFAR3 (0.46) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL53003 | 0.86 | ALOX15 (0.37) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL7657192 | 0.84 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL9717282 | 0.84 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL11870183 | 0.84 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL8336002 | 0.84 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329223-A | USING A THIOCARBOXYLIC ACID COMPOUND AND ACTIVATED CARBON | UNITED STATES BORAX & CHEMICAL CORPORATION (US) | 1982-05-11 | — | — | US | claimed |