Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Sulfotep. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfotep SCHEMBL461502 | 0.93 | TDP1 (0.39) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL11232718 | 0.91 | MEN1 (0.38) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL7762968 | 0.88 | FFAR3 (0.46) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL1163901 | 0.88 | FFAR3 (0.46) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL11233341 | 0.88 | MEN1 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL53003 | 0.88 | ALOX15 (0.37) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL9717282 | 0.86 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL7657192 | 0.86 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL11870183 | 0.86 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR | |
| Sulfotep SCHEMBL8336002 | 0.86 | ALOX15 (0.36) | MEN1KMT2ATDP1PPARDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1992308-A2 | Intracorporeal occlusive device | Microtransform, Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| US-20020135788-A1 | Image forming method and system | FUJI PHOTO FILM CO., LTD. | 2002-09-26 | — | — | US | disclosed |
| EP-1217430-A2 | Image forming method and system | Fuji Photo Film Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |
| EP-0487084-B1 | Image forming method and apparatus | CANON KK (JP) | 2002-01-30 | — | — | EP | disclosed |
| US-5864406-A | Method and apparatus for forming halftone images on organic-silver-salt-based printing plates | CANON KABUSHIKI KAISHA (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0487084-A2 | Image forming method and apparatus | CANON KABUSHIKI KAISHA (JP) | 1992-05-27 | — | — | EP | disclosed |