Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246261 | 0.87 | TSHR (0.43) | TSHRMAPTMAPK1CYP1A2CYP2D6 | |
| SCHEMBL11249163 | 0.85 | TSHR (0.44) | TSHRMAPTMAPK1CYP1A2CYP2D6 | |
| SCHEMBL11234578 | 0.84 | TSHR (0.39) | TSHRMAPTLMNAABCB11MAPK1 | |
| SCHEMBL11246464 | 0.83 | GRIN1 (0.40) | MAPK1ALDH1A1CA12CA1CA2 | |
| SCHEMBL11231543 | 0.78 | SLC6A4 (0.38) | MAPTLMNAABCB11MAPK1ALDH1A1 | |
| SCHEMBL11241229 | 0.78 | CHRNA1 (0.36) | LMNACYP2D6CYP2C19ALDH1A1KMT2A | |
| SCHEMBL11234440 | 0.78 | MEN1 (0.39) | TSHRMAPTLMNACYP1A2CYP2D6 | |
| SCHEMBL11243548 | 0.77 | ALDH1A1 (0.53) | LMNAMAPK1LTA4HALDH1A1MEN1 | |
| SCHEMBL11244135 | 0.77 | GRIN1 (0.44) | MAPTLMNAABCB11MAPK1 | |
| SCHEMBL11232065 | 0.76 | ICMT (0.35) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |