Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11249163 | 0.94 | TSHR (0.44) | TSHRCYP1A2CYP2D6CYP2C19PIM1 | |
| SCHEMBL11234367 | 0.87 | TSHR (0.40) | TSHRCYP1A2CYP2D6CYP2C19PIM1 | |
| SCHEMBL11234077 | 0.83 | TSHR (0.41) | TSHRCYP1A2CYP2D6CYP2C19PIM1 | |
| SCHEMBL11250459 | 0.81 | SMN1; SMN2 (0.38) | ALDH1A1KMT2ACA12CA1CA2 | |
| SCHEMBL11234440 | 0.81 | MEN1 (0.39) | TSHRCYP1A2CYP2D6CYP2C19LTA4H | |
| SCHEMBL11245868 | 0.78 | TSHR (0.42) | TSHRCYP1A2CYP2D6CYP2C19PIM1 | |
| SCHEMBL11242731 | 0.76 | L3MBTL1 (0.34) | CYP2D6CYP2C19HTR1AALDH1A1KMT2A | |
| SCHEMBL11239617 | 0.76 | SLC6A4 (0.37) | CYP2C19ALDH1A1CA12CA1CA2 | |
| SCHEMBL1593292 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL11237020 | 0.75 | RYR2 (0.36) | ALDH1A1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |