Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245225 | 0.87 | CASP1 (0.51) | ALDH1A1HPGDHSD17B10MAPK1CLK1 | |
| Ammonia Solution, Strong SCHEMBL11371806 | 0.85 | CASP1 (0.50) | ALDH1A1HPGDHSD17B10MAPK1CLK1 | |
| SCHEMBL11243333 | 0.83 | KDM4E (0.47) | ALDH1A1GSK3BHPGDHSD17B10MAPK1 | |
| SCHEMBL11239782 | 0.82 | GSK3B (0.41) | DHODHALDH1A1GAAGSK3BHPGD | |
| SCHEMBL11240735 | 0.81 | DHODH (0.43) | DHODHALDH1A1GAAGSK3BHPGD | |
| SCHEMBL11230958 | 0.81 | PDE4B (0.43) | DHODHALDH1A1GAAGSK3BHPGD | |
| SCHEMBL11236330 | 0.81 | ALDH1A1 (0.63) | ALDH1A1GAAGSK3BHPGDHSD17B10 | |
| SCHEMBL11233660 | 0.80 | DHODH (0.42) | DHODHALDH1A1GAAGSK3BHPGD | |
| SCHEMBL7275259 | 0.80 | PHGDH (0.48) | ALDH1A1GAAHPGDKDM4ECASP1 | |
| SCHEMBL30722885 | 0.80 | PTPN1 (0.50) | GSK3BGPR142KDM4ECDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |