Dichlorphenamide

Dichlorphenamide

SCHEMBL112376

NS(=O)(=O)c1cc(Cl)c(Cl)c(S(N)(=O)=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CA1CA12CA2CA4

The experimentally established mechanism targets of Dichlorphenamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 15/20 1.00
CA2 known ✓ P00918 15/20 1.00
CA4 known ✓ P22748 7/20 1.00
CA12 known ✓ O43570 6/20 1.00
CA9 Q16790 12/20 1.00
CA7 P43166 7/20 1.00
CA6 P23280 6/20 1.00
CA5A P35218 6/20 1.00
CA14 Q9ULX7 6/20 1.00
CA5B Q9Y2D0 6/20 1.00
CA13 Q8N1Q1 4/20 1.00
LMNA P02545 1/20 1.00
CYP2C9 P11712 1/20 1.00
APEX1 P27695 2/20 0.70
POLB P06746 1/20 0.70
TDP1 Q9NUW8 1/20 0.70
L3MBTL1 Q9Y468 1/20 0.70
CYP2C19 P33261 1/20 0.56
CA3 P07451 5/20 0.45
CISD1 Q9NZ45 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dichlorphenamide SCHEMBL29355725 1.00 CA1 (1.00) CA1CA2CA9CA4CA7
Dichlorphenamide SCHEMBL4312398 0.98 CA1 (0.96) CA1CA2CA9CA4CA7
Dichlorphenamide SCHEMBL7040074 0.98 CA1 (0.96) CA1CA2CA9CA4CA7
Dichlorphenamide SCHEMBL7034594 0.98 CA1 (0.96) CA1CA2CA9CA4CA7
SCHEMBL7993257 0.86 CA2 (0.75) CA1CA2CA9CA4CA7
Dichlorphenamide SCHEMBL298941 0.83 CA2 (0.70) CA1CA2CA9CA4CA7
SCHEMBL9518035 0.83 APEX1 (1.00) CA1CA2CA9CA4CA7
SCHEMBL17471595 0.81 CA1 (0.68) CA1CA2CA9CA4CA7
SCHEMBL11929253 0.81 CA1 (0.68) CA1CA2CA9CA4CA7
SCHEMBL9699791 0.81 CA1 (0.68) CA1CA2CA9CA4CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9520 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630599-B2 CA2 compositions and methods for tunable regulation OBSIDIAN THERAPEUTICS, INC. (US) 2026-05-19 US claimed
WO-2026090360-A1 FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE OVID THERAPEUTICS INC. (US) 2026-04-30 WO claimed
US-20260108529-A1 FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE OVID THERAPEUTICS INC (US) 2026-04-23 US claimed
EP-4724079-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Stealth BioTherapeutics Inc. (US) 2026-04-15 EP claimed
US-20260083709-A1 COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA APNIMED INC DELAWARE (US) 2026-03-26 US claimed
US-20260083692-A1 METHODS OF TREATING DISEASE WITH DICHLORPHENAMIDE STRONGBRIDGE DUBLIN LIMITED (US) 2026-03-26 US claimed
US-20260048096-A1 METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS STEALTH BIOTHERAPEUTICS INC. (US) 2026-02-19 US claimed
US-20260027139-A1 TREATMENT OF SLEEP APNEA WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ALDOSTERONE ANTAGONIST VIVUS, INC. 2026-01-29 US claimed
EP-4596049-A2 PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION Stealth BioTherapeutics Inc. (US) 2025-08-06 EP claimed
US-20250241933-A1 METHODS OF TREATING SLEEP APNEA WITH A COMBINATION OF A CANNABINOID AND A CARBONIC ANHYDRASE INHIBITOR APNIMED, INC. (DELAWARE) 2025-07-31 US claimed
EP-0126684-B1 DRUG DELIVERY SYSTEM UTILIZING THERMOSETTING GELS MERCK & CO. INC. (US) 1991-08-28 EP claimed
EP-0419311-A2 Prodrugs of carbonic anhydrase inhibitors UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1991-03-27 EP claimed
WO-1990015600-A2 TREATMENT OF CHRONIC INFLAMMATORY JOINT DISEASE WITH ARYLSULFONAMIDES A.H. ROBINS COMPANY, INCORPORATED (US) 1990-12-27 WO claimed
EP-0036351-B1 OPHTHALMIC COMPOSITIONS OF CARBONIC ANHYDRASE INHIBITORS FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1985-01-02 EP claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 EP claimed
US-4474751-A SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
EP-0014642-B1 OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF CARBONIC ANHYDRASE INHIBITORS AND S-(-)-1-(TERT-BUTYLAMINO)-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)-OXY-2-PROPANOL FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1984-03-21 EP claimed
EP-0036351-A2 Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1981-09-23 EP claimed
EP-0033042-A1 Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors MERCK & CO. INC. (US) 1981-08-05 EP claimed
EP-0014642-A2 Ophthalmic compositions comprising combinations of carbonic anhydrase inhibitors and S-(-)-1-(tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy-2-propanol for topical application in the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1980-08-20 EP claimed