Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dichlorphenamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 15/20 | 0.96 |
| ▸ | CA2 known ✓ | P00918 | 15/20 | 0.96 |
| ▸ | CA4 known ✓ | P22748 | 7/20 | 0.96 |
| ▸ | CA12 known ✓ | O43570 | 6/20 | 0.96 |
| ▸ | CA9 | Q16790 | 12/20 | 0.96 |
| ▸ | CA7 | P43166 | 7/20 | 0.96 |
| ▸ | CA6 | P23280 | 6/20 | 0.96 |
| ▸ | CA5A | P35218 | 6/20 | 0.96 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.96 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.96 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.96 |
| ▸ | APEX1 | P27695 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 5/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dichlorphenamide SCHEMBL7034594 | 1.00 | CA1 (0.96) | CA1CA2CA9CA4CA7 | |
| Dichlorphenamide SCHEMBL29355725 | 0.98 | CA1 (1.00) | CA1CA2CA9CA4CA7 | |
| Dichlorphenamide SCHEMBL112376 | 0.98 | CA1 (1.00) | CA1CA2CA9CA4CA7 | |
| Dichlorphenamide SCHEMBL4312398 | 0.96 | CA1 (0.96) | CA1CA2CA9CA4CA7 | |
| SCHEMBL7993257 | 0.84 | CA2 (0.75) | CA1CA2CA9CA4CA7 | |
| Dichlorphenamide SCHEMBL298941 | 0.82 | CA2 (0.70) | CA1CA2CA9CA4CA7 | |
| SCHEMBL9518035 | 0.81 | APEX1 (1.00) | CA1CA2CA9CA4CA7 | |
| SCHEMBL11929253 | 0.80 | CA1 (0.68) | CA1CA2CA9CA4CA7 | |
| SCHEMBL17471595 | 0.80 | CA1 (0.68) | CA1CA2CA9CA4CA7 | |
| SCHEMBL9699791 | 0.79 | CA1 (0.68) | CA1CA2CA9CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030077302-A1 | Diclofenamide suspension gel | DR. GERHARD MANN CHEM.-PHARM. FABRIK GMGH (DE) | 2003-04-24 | — | — | US | disclosed |