Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.75 |
| ▸ | CA1 | P00915 | 14/20 | 0.75 |
| ▸ | CA9 | Q16790 | 11/20 | 0.75 |
| ▸ | CA7 | P43166 | 4/20 | 0.75 |
| ▸ | CA4 | P22748 | 4/20 | 0.75 |
| ▸ | CA12 | O43570 | 3/20 | 0.75 |
| ▸ | CA6 | P23280 | 3/20 | 0.75 |
| ▸ | CA5A | P35218 | 3/20 | 0.75 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.75 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.75 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | APEX1 | P27695 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CA3 | P07451 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dichlorphenamide SCHEMBL112376 | 0.86 | CA1 (1.00) | CA2CA1CA9CA7CA4 | |
| Dichlorphenamide SCHEMBL29355725 | 0.86 | CA1 (1.00) | CA2CA1CA9CA7CA4 | |
| Dichlorphenamide SCHEMBL7034594 | 0.84 | CA1 (0.96) | CA2CA1CA9CA7CA4 | |
| Dichlorphenamide SCHEMBL7040074 | 0.84 | CA1 (0.96) | CA2CA1CA9CA7CA4 | |
| Dichlorphenamide SCHEMBL4312398 | 0.84 | CA1 (0.96) | CA2CA1CA9CA7CA4 | |
| SCHEMBL3781532 | 0.82 | CA1 (1.00) | CA2CA1CA9CA7CA4 | |
| SCHEMBL5564627 | 0.80 | CA1 (0.64) | CA2CA1CA9CA7CA4 | |
| SCHEMBL2535790 | 0.80 | CA2 (0.56) | CA2CA1CA9CA7CA4 | |
| SCHEMBL4333676 | 0.78 | CA1 (0.48) | CA2CA1CA9CA7CA4 | |
| SCHEMBL11929253 | 0.77 | CA1 (0.68) | CA2CA1CA9CA7CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5354778-A | N-Phenyl-N'-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5234955-A | N-phenyl-N*-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |