SCHEMBL11237700

SCHEMBL11237700

CCCCCN[C@H]1CN(S(=O)(=O)O)C1=O

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAN2B1 O00754 1/20 0.36
GBA1 P04062 7/20 0.35
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
NAAA Q02083 3/20 0.33
S1PR4 O95977 1/20 0.33
S1PR1 P21453 1/20 0.33
S1PR3 Q99500 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10678300 1.00 MAN2B1 (0.36) MAN2B1GBA1CA1CA2NAAA
SCHEMBL9800800 0.79 MAN2B1 (0.39) MAN2B1GBA1NAAAS1PR4S1PR1
SCHEMBL10052051 0.74
SCHEMBL10679465 0.73 CA12 (0.33) CA1CA2NAAA
SCHEMBL10679459 0.73 CA12 (0.33) CA1CA2NAAA
SCHEMBL11036205 0.73 MAN2B1 (0.35) MAN2B1GBA1NAAA
SCHEMBL9800835 0.72 FAAH (0.35) MAN2B1GBA1NAAA
SCHEMBL9800830 0.71 NAAA (0.34) MAN2B1GBA1NAAA
SCHEMBL10678594 0.70 NSD2 (0.34) CA1CA2
SCHEMBL10713568 0.70 MAN2B1 (0.33) MAN2B1GBA1NAAAS1PR4S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4421686-A 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones E. R. SQUIBB & SONS, INC. (US) 1983-12-20 US disclosed