Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11228891 | 0.86 | MEN1 (0.47) | KMT2AMAPTMEN1PPARAPPARG | |
| SCHEMBL5037444 | 0.79 | PIN1 (0.45) | MAPTCYP1A2CYP3A4TSHRLMNA | |
| SCHEMBL5037447 | 0.79 | PIN1 (0.45) | MAPTCYP1A2CYP3A4TSHRLMNA | |
| SCHEMBL7861200 | 0.78 | PIN1 (0.50) | KMT2AMAPTMEN1PPARAABCB11 | |
| SCHEMBL1967184 | 0.78 | MMP8 (0.49) | KMT2A | |
| SCHEMBL10334686 | 0.76 | PPARA (0.50) | KMT2AMAPTMEN1PPARACYP1A2 | |
| SCHEMBL16672541 | 0.76 | ALDH1A1 (0.49) | KMT2AMEN1CYP3A4TSHRLMNA | |
| SCHEMBL11044937 | 0.76 | PPARA (0.46) | KMT2AMAPTMEN1PPARAPPARG | |
| SCHEMBL11247181 | 0.76 | PPARA (0.46) | KMT2AMAPTMEN1PPARAPPARG | |
| SCHEMBL11249627 | 0.76 | PPARA (0.46) | KMT2AMAPTMEN1PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009306-B1 | ANTI-ARTHRITIC HYDROXYACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-24 | — | — | EP | disclosed |
| US-4310544-A | Hydroxyacetic acid derivatives with anti-arthritic properties | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-01-12 | — | — | US | disclosed |
| EP-0009306-A1 | Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |