Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.31 |
| ▸ | CIT | O14578 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.31 |
| ▸ | STK10 | O94804 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245015 | 0.87 | PDE3B (0.39) | AAK1MAPK1AKT1AKT2MAP4K1 | |
| SCHEMBL11240784 | 0.82 | PDE3B (0.46) | MAPK1AKT1AKT2MAP4K1ROCK2 | |
| SCHEMBL11231193 | 0.77 | MAPK1 (0.39) | MAPK1AKT1AKT2GSK3B | |
| SCHEMBL11382554 | 0.77 | GSK3B (0.38) | AAK1ROCK2GSK3BKCNH2DYRK1A | |
| SCHEMBL11244896 | 0.72 | GSK3B (0.49) | MAPK1AKT1ROCK2ROCK1GSK3B | |
| SCHEMBL11238221 | 0.72 | PDE3B (0.41) | AAK1MAPK1AKT1AKT2GSK3B | |
| SCHEMBL11227748 | 0.71 | MAPT (0.39) | AAK1MAPK1AKT1AKT2ROCK2 | |
| SCHEMBL11165444 | 0.70 | GSK3B (0.40) | AAK1GSK3BPDE3BPDE3A | |
| SCHEMBL11246839 | 0.70 | GSK3B (0.38) | MAPK1AKT1AKT2ROCK2GSK3B | |
| SCHEMBL11367530 | 0.70 | PDE3B (0.40) | MAPK1BRAFMAPK3JAK2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |