Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11229212 | 0.99 | MEN1 (0.46) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL11226228 | 0.83 | NR2E1 (0.50) | MEN1KMT2AMAPTMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL11734283 | 0.82 | NR2E1 (0.49) | MEN1KMT2AMAPTMAPK1TDP1 | |
| SCHEMBL11143175 | 0.79 | ADRB2 (0.69) | MEN1KMT2AMAPTTDP1ADRB2 | |
| Xibenolol SCHEMBL79880 | 0.76 | CYP2D6 (0.70) | MEN1KMT2AMAPTADRB2ADRB1 | |
| Xibenolol SCHEMBL79879 | 0.76 | CYP2D6 (0.70) | MEN1KMT2AMAPTADRB2ADRB1 | |
| Xibenolol SCHEMBL29387811 | 0.76 | CYP2D6 (0.70) | MEN1KMT2AMAPTADRB2ADRB1 | |
| Xibenolol SCHEMBL6506961 | 0.76 | CYP2D6 (0.70) | MEN1KMT2AMAPTADRB2ADRB1 | |
| SCHEMBL11233401 | 0.75 | ALOX5 (0.51) | MEN1KMT2AADRB2ADRB1CYP2D6 | |
| Xibenolol SCHEMBL7267198 | 0.75 | CYP2D6 (0.72) | MEN1KMT2AMAPTADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018824-A | ANTIULCER AND ADRENERGIC BLOCKING AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1977-04-19 | — | — | US | claimed |
| US-4360464-A | Process for production of 1-aryloxy-aminopropane derivatives | TEIKOKU HORMONE MFG. CO. LTD. (JP) | 1982-11-23 | — | — | US | disclosed |
| US-4018824-A | ANTIULCER AND ADRENERGIC BLOCKING AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1977-04-19 | — | — | US | disclosed |