Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241085 | 0.84 | MAPT (0.36) | MAPTALDH1A1MAP4K1MEN1KMT2A | |
| SCHEMBL11234732 | 0.83 | PDE7A (0.38) | MAPTALDH1A1CYP19A1NPC1RAB9A | |
| SCHEMBL3791741 | 0.83 | DHFR (0.40) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL11240092 | 0.81 | TSHR (0.39) | MAPTALDH1A1NPC1RAB9ACYP3A4 | |
| SCHEMBL13398588 | 0.81 | HSD17B10 (0.47) | ALDH1A1CYP19A1CYP3A4TSHRRECQL | |
| SCHEMBL11241124 | 0.77 | ROCK2 (0.43) | ROCK2CYP19A1MAP4K1CYP3A4CCNC | |
| SCHEMBL3789449 | 0.76 | MAP2K3 (0.44) | MAPTALDH1A1NPC1RAB9ACYP3A4 | |
| SCHEMBL29363024 | 0.75 | HSP90AA1 (0.50) | ALDH1A1CYP19A1NPC1RAB9ACYP3A4 | |
| SCHEMBL3786754 | 0.75 | HSP90AA1 (0.50) | ALDH1A1CYP19A1NPC1RAB9ACYP3A4 | |
| SCHEMBL28794566 | 0.72 | MEN1 (0.41) | MAPTALDH1A1NPC1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |