Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222659 | 0.95 | MTNR1A (0.49) | MTNR1AMTNR1BMAPK1NAMPTDRD2 | |
| SCHEMBL11243423 | 0.88 | MTNR1A (0.54) | MTNR1AMTNR1BMAPK1NAMPTDRD2 | |
| SCHEMBL2827572 | 0.87 | DAPK3 (0.49) | MTNR1AMTNR1BMAPK1NAMPTDRD2 | |
| SCHEMBL13373448 | 0.86 | MTNR1A (0.43) | MTNR1AMTNR1BMAPK1FLT3 | |
| SCHEMBL2827001 | 0.82 | EPHX2 (0.46) | MAPK1NAMPTDRD2DRD3DAPK3 | |
| SCHEMBL17483733 | 0.77 | DRD2 (0.48) | MAPK1NAMPTDRD2DRD3DAPK3 | |
| SCHEMBL2206759 | 0.76 | PRKACA (0.50) | MAPK1NAMPTDRD2DRD3DAPK3 | |
| SCHEMBL12338145 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BMAPK1MAPK8CDK2 | |
| SCHEMBL16118864 | 0.73 | DRD2 (0.45) | MAPK1NAMPTDRD2DRD3DAPK3 | |
| SCHEMBL16118861 | 0.73 | DRD2 (0.45) | MAPK1NAMPTDRD2DRD3DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322540-A | PROLACTIN INHIBITOR | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| US-4322430-A | Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| US-4276300-A | PROLACTIN INHIBITORS | ELI LILLY AND COMPANY (US) | 1981-06-30 | — | — | US | disclosed |