Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | ICMT | O60725 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252318 | 0.92 | MAPK1 (0.40) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL1594432 | 0.89 | L3MBTL1 (0.43) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL11250471 | 0.87 | L3MBTL1 (0.42) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL12134272 | 0.83 | L3MBTL1 (0.47) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL11234154 | 0.82 | SLC6A4 (0.35) | TSHRMAPK1ICMTALDH1A1 | |
| SCHEMBL11232065 | 0.82 | ICMT (0.35) | HTR1AICMT | |
| SCHEMBL10339449 | 0.82 | L3MBTL1 (0.46) | L3MBTL1TSHRMAPK1SMN1; SMN2ICMT | |
| SCHEMBL11242731 | 0.81 | L3MBTL1 (0.34) | L3MBTL1HTR1AICMTALDH1A1CYP3A4 | |
| SCHEMBL11248214 | 0.81 | SLC6A3 (0.34) | SMN1; SMN2ICMTMEN1KMT2A | |
| SCHEMBL11250979 | 0.80 | SLC6A3 (0.41) | ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732339-B | Dapoxetine hydrochloride intermediate and preparation method thereof | 上海医药工业研究院 | 2019-06-04 | — | — | CN | disclosed |
| CN-105732339-A | Dapoxetine intermediate and preparation method thereof | 上海医药工业研究院 | 2016-07-06 | — | — | CN | disclosed |
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |