Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250471 | 0.95 | L3MBTL1 (0.42) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL11240674 | 0.89 | L3MBTL1 (0.45) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL11243389 | 0.88 | TSHR (0.37) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL10339449 | 0.86 | L3MBTL1 (0.46) | L3MBTL1TSHRMAPK1SMN1; SMN2CHRM2 | |
| SCHEMBL1593553 | 0.86 | LTA4H (0.39) | TSHRHTR1A | |
| SCHEMBL1593327 | 0.84 | ALDH1A1 (0.33) | TSHRMAPK1ALDH1A1MAOAMAOB | |
| SCHEMBL10976001 | 0.83 | GRIN1 (0.37) | L3MBTL1TSHRMAPK1SMN1; SMN2HTR1A | |
| SCHEMBL4053345 | 0.82 | EGFR (0.32) | SMN1; SMN2MEN1KMT2AMAOAMAOB | |
| SCHEMBL4613107 | 0.82 | L3MBTL1 (0.33) | L3MBTL1KMT2AMAOAMAOB | |
| SCHEMBL1594054 | 0.82 | PKM (0.34) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924578-B1 | 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2013-11-06 | — | — | EP | disclosed |
| US-20130231360-A1 | Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases | THE BRIGHAM AND WOMEN S HOSPITAL, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231360-A1 | Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases | THE BRIGHAM AND WOMEN S HOSPITAL, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8217001-B2 | Modification of feeding behavior | IMPERIAL INNOVATIONS LIMITED | 2012-07-10 | — | — | US | disclosed |
| WO-2011133795-A2 | BETA-CARBOLINES AS INHIBITORS OF HASPIN AND DYRK KINASES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| US-7981882-B2 | e.g. 7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine; antidepressant, anxiolytic agent; obesity, obsessive/compulsive disorder | ELI LILLY AND COMPANY (US) | 2011-07-19 | — | — | US | disclosed |
| US-7919329-B2 | Using proopiomelanocortin neuronal regulatory sequences to identify agents that affects caloric intake, energy expenditure, appetite or food intake; treating eating disorders and/or cachexia | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2011-04-05 | — | — | US | disclosed |
| US-20090209461-A1 | MODIFICATION OF FEEDING BEHAVIOR | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 2009-08-20 | — | — | US | disclosed |
| EP-2050460-A1 | PYY and agonists thereof for modification of feeding behaviour | Imperial Innovations Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| US-7459432-B2 | Modification of feeding behavior | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 2008-12-02 | — | — | US | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |
| US-5089529-A | Antiarrhythmia agents | NIPPON SHINYAKU CO., LTD. (JP) | 1992-02-18 | — | — | US | disclosed |
| US-4603134-A | ANTIHISTAMINES | FERRER INTERNATIONAL, S.A. (ES) | 1986-07-29 | — | — | US | disclosed |
| US-4294986-A | Novel para-phenylalkoxy phenylurea and thiourea compounds and herbicidal use thereof | AMERICAN CYANAMID CO. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4289903-A | PREEMERGENCE AND POSTEMERGENCE | AMERICAN CYANAMID COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| US-4258045-A | 2,4-DIAMINO-5-((ARYLALKOXY)BENZYL)-PYRIMIDINES AS ANTIBACTERIAL, ANTIPROTOZOAL AND ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4241070-A | NONHABIT-FORMING | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-12-23 | — | — | US | disclosed |
| US-4101662-A | DISUBSTITUTED PIPERIDINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1978-07-18 | — | — | US | disclosed |
| US-3997670-A | HYPOLIPIDEMIC | SANDOZ, INC. (US) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209461-A1 | MODIFICATION OF FEEDING BEHAVIOR | NPY4R, NPY5R, NPY2R | L3MBTL1 1954/4885TSHR 120/4885MAPK1 3627/4885 |
| US-20130231360-A1 | Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases | HASPIN, HIPK1, HIPK2 | L3MBTL1 2915/4885TSHR 3225/4885MAPK1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.