Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 5/20 | 0.41 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124137 | 0.82 | TGM2 (0.54) | TGM2HDAC4DHODHALDH1A1 | |
| SCHEMBL1124077 | 0.77 | TGM2 (0.58) | TGM2HDAC4PDGFRAKDRALDH1A1 | |
| SCHEMBL732934 | 0.77 | TGM2 (0.81) | TGM2ALDH1A1CDK13LMNA | |
| SCHEMBL1124538 | 0.77 | TGM2 (0.61) | TGM2ALDH1A1CDK7CDK13 | |
| SCHEMBL2334562 | 0.77 | POLB (0.55) | TGM2HDAC4WNT3APDGFRAKDR | |
| SCHEMBL19889047 | 0.76 | TGM2 (0.65) | TGM2HDAC4ALDH1A1LMNA | |
| SCHEMBL24633926 | 0.76 | TGM2 (0.56) | TGM2HDAC4ALDH1A1CDK7CDK13 | |
| SCHEMBL1124045 | 0.76 | TGM2 (0.52) | TGM2WNT3APDGFRAKDRALDH1A1 | |
| SCHEMBL19888952 | 0.76 | MGLL (0.56) | TGM2ALDH1A1POLBLMNA | |
| SCHEMBL2028394 | 0.73 | TGM2 (0.52) | TGM2PDGFRAKDRALDH1A1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282996-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-02-16 | — | — | EP | claimed |
| WO-2009141782-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-26 | — | — | WO | claimed |
| EP-2282996-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141782-A1 | TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-26 | — | — | WO | disclosed |