SCHEMBL1124137

SCHEMBL1124137

C=CC(=O)NCc1ccc(-c2ccccn2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.54
HPGDS O60760 4/20 0.48
EPHX1 P07099 1/20 0.47
CYP2D6 P10635 1/20 0.47
EPHX2 P34913 1/20 0.47
CHRM4 P08173 1/20 0.46
HCAR2 Q8TDS4 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
DHODH Q02127 1/20 0.42
TAOK1 Q7L7X3 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1124077 0.84 TGM2 (0.58) TGM2HPGDSCYP2D6EPHX2HDAC3
SCHEMBL2773101 0.82 HPGDS (0.56) HPGDSEPHX1CYP2D6EPHX2CHRM4
SCHEMBL1124045 0.82 TGM2 (0.52) TGM2CHRM4ALDH1A1
SCHEMBL1124107 0.82 TGM2 (0.52) TGM2HDAC4DHODHALDH1A1
SCHEMBL19889047 0.81 TGM2 (0.65) TGM2CYP2D6EPHX2HDAC3HDAC4
SCHEMBL27593845 0.80 HPGDS (0.68) HPGDSEPHX2HDAC3HDAC4HDAC1
SCHEMBL732934 0.78 TGM2 (0.81) TGM2CYP2D6MEN1ALDH1A1KMT2A
SCHEMBL1124538 0.78 TGM2 (0.61) TGM2KDM4EALDH1A1
SCHEMBL2028394 0.77 TGM2 (0.52) TGM2HPGDSCYP2D6HDAC1ALDH1A1
SCHEMBL40744 0.77 TGM2 (0.68) TGM2EPHX1CYP2D6MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2358673-A1 NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS Actelion Pharmaceuticals Ltd. (CH) 2011-08-24 EP claimed
EP-2282996-A1 TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS Actelion Pharmaceuticals Ltd. (CH) 2011-02-16 EP claimed
WO-2010058353-A1 NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2010-05-27 WO claimed
WO-2009141782-A1 TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2009-11-26 WO claimed
EP-1940814-A1 PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS Actelion Pharmaceuticals Ltd. (CH) 2008-07-09 EP claimed
WO-2007046075-A1 PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2007-04-26 WO claimed
EP-2358673-A1 NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS Actelion Pharmaceuticals Ltd. (CH) 2011-08-24 EP disclosed
EP-2282996-A1 TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS Actelion Pharmaceuticals Ltd. (CH) 2011-02-16 EP disclosed
WO-2010058353-A1 NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2010-05-27 WO disclosed
WO-2009141782-A1 TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS ACTELION PHARMACEUTICALS LTD (CH) 2009-11-26 WO disclosed