Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251060 | 0.89 | TGFBR1 (0.43) | CDK5CDK5R1TGFBR1CCR1CCR8 | |
| SCHEMBL11239015 | 0.81 | PDE3B (0.41) | TGFBR1CCR1CCR8 | |
| SCHEMBL11242528 | 0.81 | CCR1 (0.40) | CDK5CDK5R1TGFBR1CCR1CCR8 | |
| SCHEMBL11235398 | 0.78 | GAA (0.45) | KDM4EGAAHPGDHSD17B10TGFBR1 | |
| SCHEMBL11242990 | 0.76 | TGFBR1 (0.35) | CDK5CDK5R1TGFBR1CCR1CCR8 | |
| SCHEMBL11231230 | 0.74 | CCR1 (0.44) | TGFBR1CCR1CCR8 | |
| SCHEMBL11238710 | 0.74 | CDK5 (0.49) | KDM4EGAAHPGDHSD17B10CDK5 | |
| SCHEMBL16277390 | 0.70 | SORT1 (0.55) | SORT1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL7847744 | 0.68 | KDM4E (0.56) | SORT1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL6609571 | 0.67 | ALDH1A1 (0.58) | SORT1KDM4EHPGDTGFBR1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312875-A | 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-01-26 | — | — | US | disclosed |