Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394435 | 0.91 | ICMT (0.32) | ICMTKCNH2 | |
| SCHEMBL11233432 | 0.86 | NPC1 (0.40) | ICMTNPC1RAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL7885222 | 0.84 | HDAC3 (0.33) | ICMTSMN1; SMN2 | |
| SCHEMBL11237330 | 0.83 | KCNH2 (0.41) | ICMTNPC1RAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL11231543 | 0.83 | SLC6A4 (0.38) | ICMTLMNAMAPK1 | |
| SCHEMBL11241229 | 0.83 | CHRNA1 (0.36) | ICMTLMNA | |
| SCHEMBL11232065 | 0.81 | ICMT (0.35) | ICMT | |
| SCHEMBL11246464 | 0.79 | GRIN1 (0.40) | ICMTSMN1; SMN2MAPK1 | |
| SCHEMBL4610723 | 0.77 | RAB9A (0.35) | ICMTNPC1RAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL11254777 | 0.75 | SIGMAR1 (0.32) | ICMTNPC1RAB9ASMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |