Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | PON1 | P27169 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237330 | 0.94 | KCNH2 (0.41) | NPC1RAB9ASMN1; SMN2ICMTKCNH2 | |
| SCHEMBL4610723 | 0.90 | RAB9A (0.35) | NPC1RAB9ASMN1; SMN2ICMTKCNH2 | |
| SCHEMBL11242322 | 0.86 | ICMT (0.35) | NPC1RAB9ASMN1; SMN2ICMTKCNH2 | |
| SCHEMBL11242731 | 0.81 | L3MBTL1 (0.34) | ICMTLMNA | |
| SCHEMBL11254777 | 0.79 | SIGMAR1 (0.32) | NPC1RAB9ASMN1; SMN2ICMTKCNH2 | |
| SCHEMBL11234154 | 0.79 | SLC6A4 (0.35) | ICMTTSHRLMNAMAPTPOLB | |
| SCHEMBL11238469 | 0.79 | POLB (0.33) | NPC1RAB9ASMN1; SMN2TSHRSIGMAR1 | |
| SCHEMBL11248214 | 0.77 | SLC6A3 (0.34) | SMN1; SMN2ICMTLMNA | |
| SCHEMBL3394435 | 0.77 | ICMT (0.32) | ICMTKCNH2 | |
| SCHEMBL11240674 | 0.77 | L3MBTL1 (0.45) | SMN1; SMN2ICMTTSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |