Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.34 |
| ▸ | CHRNG | P07510 | 2/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRND | Q07001 | 2/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256266 | 0.88 | SLC6A2 (0.32) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL11243234 | 0.87 | SOAT1 (0.33) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL11239752 | 0.85 | SOAT1 (0.44) | SOAT1 | |
| SCHEMBL11238469 | 0.83 | POLB (0.33) | SOAT1 | |
| SCHEMBL11236878 | 0.83 | SOAT1 (0.37) | SLC6A3SLC6A4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL11230749 | 0.81 | MAOA (0.33) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL11245526 | 0.78 | HMOX1 (0.38) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL11234440 | 0.78 | MEN1 (0.39) | SOAT1 | |
| SCHEMBL11253974 | 0.76 | — | — | |
| SCHEMBL11234154 | 0.76 | SLC6A4 (0.35) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |