Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | HTR2B | P41595 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238737 | 0.86 | PIM1 (0.41) | HTR2CHTR2BHTR2APIM1PARP1 | |
| SCHEMBL7400974 | 0.84 | PARP1 (0.47) | HTR2CHTR2BHTR2APARP1MAOA | |
| Hydrochloric Acid SCHEMBL11101784 | 0.82 | PARP1 (0.46) | HTR2CHTR2BHTR2APARP1MAOA | |
| SCHEMBL11256455 | 0.82 | P2RX4 (0.48) | MAOAMAOBGAAP2RX4 | |
| SCHEMBL38662568 | 0.78 | PIM1 (0.49) | HTR2CHTR2BHTR2APIM1CACNA1B | |
| SCHEMBL9280480 | 0.77 | HTR2C (0.56) | HTR2CHTR2BHTR2APARP1 | |
| SCHEMBL11247722 | 0.75 | HTR2C (0.50) | HTR2CHTR2BHTR2APARP1GAA | |
| SCHEMBL11247293 | 0.73 | HTR2C (0.49) | HTR2CHTR2BHTR2APARP1MAOA | |
| SCHEMBL357767 | 0.73 | HTR2C (0.51) | HTR2CHTR2BHTR2A | |
| SCHEMBL9522239 | 0.72 | HTR2C (0.43) | HTR2CHTR2BHTR2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360525-A | NEUROLEPTIC AGENTS, ANTIDEPRESSANTS, SLEEP PROMOTERS | SANDOZ LTD. (CH) | 1982-11-23 | — | — | US | claimed |
| EP-0026469-A1 | Dibenzazepine derivatives, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-04-08 | — | — | EP | claimed |
| US-4360525-A | NEUROLEPTIC AGENTS, ANTIDEPRESSANTS, SLEEP PROMOTERS | SANDOZ LTD. (CH) | 1982-11-23 | — | — | US | disclosed |