Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394339 | 0.83 | PTGS2 (0.49) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL3155111 | 0.83 | PTGS2 (0.49) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL9119656 | 0.83 | PTGS2 (0.49) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL23527437 | 0.78 | GABRA1 (0.62) | GABRA1GABRB2CTNNB1 | |
| SCHEMBL11246916 | 0.78 | TDP1 (0.58) | GABRA1GABRB2PTGS2CXCL8CTNNB1 | |
| SCHEMBL11263281 | 0.78 | PDE3B (0.42) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL2466822 | 0.77 | PTGS2 (0.44) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL17491866 | 0.77 | PTGS2 (0.50) | PTGS1PTGS2LMNACXCR1CXCR2 | |
| SCHEMBL287453 | 0.75 | AKR1C3 (0.44) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL8120419 | 0.74 | AKR1B1 (0.51) | PTGS1PTGS2LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4356188-A | ANTIINFLAMMATORY AND ANTIPYRETIC AGENTS; ANALGESICS | INSTITUT DE RECHERCHE SCIENTIFIQUE "I.R.S." (FR) | 1982-10-26 | — | — | US | claimed |
| US-4356188-A | ANTIINFLAMMATORY AND ANTIPYRETIC AGENTS; ANALGESICS | INSTITUT DE RECHERCHE SCIENTIFIQUE "I.R.S." (FR) | 1982-10-26 | — | — | US | disclosed |