Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263122 | 0.80 | POLB (0.43) | PTGS2PTGS1LMNACXCR1CXCR2 | |
| SCHEMBL298816 | 0.80 | CYP2A6 (0.40) | PTGS2PTGS1CXCR1CXCR2CXCL8 | |
| SCHEMBL11243028 | 0.78 | GABRA1 (0.46) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL11251937 | 0.78 | TDP1 (0.46) | PDE3BPDE3APTGS2LMNAPOLB | |
| SCHEMBL11266799 | 0.77 | POLB (0.39) | PTGS2PTGS1CXCL8TSHRPOLB | |
| SCHEMBL11256929 | 0.73 | RAB9A (0.40) | PTGS2LMNAAKR1C3AKR1C2MAPK1 | |
| SCHEMBL11255431 | 0.72 | SELPLG (0.44) | PDE3BPDE3ALMNACYP2C9CXCL8 | |
| SCHEMBL11259590 | 0.72 | TRPV1 (0.37) | PTGS2CYP2C9CXCL8MMP1MMP2 | |
| SCHEMBL11257836 | 0.72 | BCHE (0.41) | PDE3BPDE3APTGS2AKR1C3AKR1C2 | |
| SCHEMBL11251904 | 0.71 | CXCL8 (0.35) | PTGS2PTGS1AKR1C3CXCL8ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |