Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29155847 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1AKR1C3LMNACXCR1 | |
| SCHEMBL3155111 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL9119656 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL1394339 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL5983552 | 0.79 | PTGS2 (0.46) | PTGS2PTGS1AKR1C3LMNACXCR1 | |
| SCHEMBL5112475 | 0.79 | PTGS2 (0.46) | PTGS2PTGS1AKR1C3LMNACXCR1 | |
| SCHEMBL30222272 | 0.79 | PTGS2 (0.46) | PTGS2PTGS1AKR1C3LMNACXCR1 | |
| SCHEMBL20954008 | 0.79 | GABRA1 (0.47) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL11243028 | 0.77 | GABRA1 (0.46) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL6916097 | 0.77 | GABRA1 (0.48) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150030549-A1 | TOPICAL COMPOSITIONS | GREEN MONIQUE RENATA (US) | 2015-01-29 | — | — | US | disclosed |
| EP-1858503-B1 | TOPICAL GELS COMPOSITIONS | GREEN MONIQUE RENATA (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20110217248-A1 | Topical Composition | ISW GROUP, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20100158993-A1 | Topical Gel Compositions | ISW GROUP, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| EP-2066313-A2 | TOPICAL COMPOSITIONS | ISW Group Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20080317684-A1 | Topical Compositions | ISW GROUP, INC. (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008030359-A2 | TOPICAL COMPOSITIONS | ISW GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
| EP-1858503-A1 | TOPICAL GELS COMPOSITIONS | ISW Group Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| US-20070053984-A1 | Topical gels compositions | SPANN-WADE MONIQUE | 2007-03-08 | — | — | US | disclosed |
| WO-2006096360-A1 | TOPICAL GELS COMPOSITIONS | ISW GROUP, INC. (US) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070053984-A1 | Topical gels compositions | PTGES, PTGER1, S100A8 | PTGS2 15/4885PTGS1 4/4885AKR1C3 84/4885 |
| US-20150030549-A1 | TOPICAL COMPOSITIONS | PTGER1, PTGES, PTGIS | PTGS2 11/4885PTGS1 4/4885AKR1C3 515/4885 |
| US-20110217248-A1 | Topical Composition | S100A8, S100P, BPTF | PTGS2 107/4885PTGS1 76/4885AKR1C3 931/4885 |
| US-20100158993-A1 | Topical Gel Compositions | PTGES, PTGER1, PTGS1 | PTGS2 14/4885PTGS1 3/4885AKR1C3 85/4885 |
| US-20080317684-A1 | Topical Compositions | PTGER1, PTGES, PTGIS | PTGS2 11/4885PTGS1 4/4885AKR1C3 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.