Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29440798 | 0.91 | GPR84 (0.44) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL25753850 | 0.90 | TSHR (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL11484034 | 0.88 | AKR1B1 (0.42) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL28325549 | 0.88 | NOS3 (0.43) | ALDH1A1TDP1KMT2AMEN1NOS3 | |
| SCHEMBL28380157 | 0.85 | HSD17B10 (0.38) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL11175379 | 0.84 | GPR84 (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL10911110 | 0.84 | GPR84 (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL27831391 | 0.84 | THRB (0.39) | TSHRALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL10911077 | 0.84 | GPR84 (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL4230488 | 0.84 | THRB (0.39) | TSHRALDH1A1KMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323517-A | ANTIPHLOGISTIC AGENTS | TROPONWERKE GMBH & CO. KG (DE) | 1982-04-06 | — | — | US | disclosed |
| US-4246278-A | ANTIINFLAMMATORY SULFUR-CONTAINING ORGANIC ACIDS OR ESTERS OR THIOATES | BAYER AKTIENGESELLSCHAFT (DE) | 1981-01-20 | — | — | US | disclosed |
| EP-0002219-B1 | MEDICINES WITH SULFUR CONTAINING ESTERS, AND THEIR PREPARATION | Troponwerke GmbH & Co. KG (DE) | 1980-12-10 | — | — | EP | disclosed |
| EP-0002219-A1 | Medicines with sulfur containing esters, and their preparation | Troponwerke GmbH & Co. KG (DE) | 1979-06-13 | — | — | EP | disclosed |