Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27831391 | 1.00 | THRB (0.39) | THRBHSD17B10CES2GMNNTP53 | |
| SCHEMBL9246948 | 0.84 | LMNA (0.40) | THRBHSD17B10CES2GMNNTP53 | |
| SCHEMBL11243793 | 0.84 | GPR84 (0.44) | HSD17B10CES2MAPTTSHRNOS3 | |
| SCHEMBL28380157 | 0.83 | HSD17B10 (0.38) | THRBHSD17B10CES2GMNNTP53 | |
| Ethylene Glycol SCHEMBL27667824 | 0.80 | LMNA (0.42) | THRBHSD17B10CES2GMNNTP53 | |
| Ethylene Glycol SCHEMBL27430969 | 0.80 | LMNA (0.42) | THRBHSD17B10CES2GMNNTP53 | |
| Ethylene Glycol SCHEMBL28747908 | 0.80 | LMNA (0.42) | THRBHSD17B10CES2GMNNTP53 | |
| SCHEMBL35565 | 0.80 | THRB (0.42) | THRBHSD17B10CES2GMNNTP53 | |
| SCHEMBL10571256 | 0.80 | THRB (0.42) | THRBHSD17B10CES2GMNNTP53 | |
| SCHEMBL11170048 | 0.80 | THRB (0.42) | THRBHSD17B10CES2GMNNTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170146-A1 | Novel Carboxylesterase Nucleic Acid Molecules, Proteins and Uses Thereof | WELLS FARGO BUSINESS CREDIT, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20040081998-A1 | Novel carboxylesterase nucleic acid molecules, proteins and uses thereof | SILVER GARY M (US) | 2004-04-29 | — | — | US | disclosed |
| US-6664090-B1 | Use as therapeutic compositions to protect animals from hematophagous arthropod (flea) infestations | HESKA CORPORATION | 2003-12-16 | — | — | US | disclosed |
| US-6291222-B1 | ANTIBODIES; ENZYME INHIBITORS; FLEAS; GENETIC ENGINEERING | HESKA CORPORATION | 2001-09-18 | — | — | US | disclosed |
| US-6063610-A | FLEA HYDROLASE ENZYME; FOR DEVELOPMENT OF ANTIBODIES TO PREVENT PARASITIC INFECTION OF PLANT AND ANIMALS | HESKA CORPORATION (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0942970-A1 | NOVEL CARBOXYLESTERASE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF | Heska Corporation (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998021324-A1 | NOVEL CARBOXYLESTERASE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF | HESKA CORPORATION (US) | 1998-05-22 | — | — | WO | disclosed |