Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11285758 | 0.88 | CES2 (0.38) | CES2CES1LOXL2ALDH1A1HPGD | |
| SCHEMBL6503361 | 0.83 | CALM1 (0.41) | CES2CES1LOXL2ALDH1A1HPGD | |
| SCHEMBL11277452 | 0.82 | HDAC3 (0.43) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL11287973 | 0.82 | ALDH1A1 (0.41) | CES2CES1LOXL2ALDH1A1HPGD | |
| SCHEMBL11288432 | 0.80 | TDP1 (0.41) | CES2CES1HPGDHDAC3HDAC4 | |
| SCHEMBL17104769 | 0.80 | TP53 (0.39) | CES2CES1MAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL10333077 | 0.80 | CALM1 (0.32) | CES2CES1LOXL2ALDH1A1ALOX15 | |
| SCHEMBL10805196 | 0.79 | HDAC3 (0.53) | CES2CES1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL9626044 | 0.78 | CALM1 (0.31) | CES2CES1ALDH1A1HPGDALOX15 | |
| Benzene SCHEMBL11030926 | 0.78 | CALM1 (0.45) | CES2CES1LOXL2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022495-B1 | 2-ALKOXYPHENYL-IMIDAZO(4,5-B)PYRIDINES, THEIR PREPARATION, THEIR USE IN THE PRODUCTION OF MEDICAMENTS AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1982-06-16 | — | — | EP | disclosed |
| US-4327100-A | USEFUL AS HYPERTENSIVE AND CARDIOTONIC AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-04-27 | — | — | US | disclosed |
| EP-0022495-A1 | 2-Alkoxyphenyl-imidazo(4,5-b)pyridines, their preparation, their use in the production of medicaments and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1981-01-21 | — | — | EP | disclosed |