Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247022 | 0.87 | ALDH1A1 (0.47) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11251381 | 0.85 | FFAR4 (0.77) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11255027 | 0.80 | FFAR4 (0.63) | FFAR4ALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL11257225 | 0.80 | FFAR4 (0.63) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11234752 | 0.76 | FFAR4 (0.61) | FFAR4NPSR1PTPN1SMN1; SMN2TP53 | |
| SCHEMBL10662256 | 0.76 | ALDH1A1 (0.44) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11243606 | 0.74 | FFAR4 (0.55) | FFAR4ALDH1A1KDM4EHPGDPTPN1 | |
| SCHEMBL27439734 | 0.73 | PKM (0.50) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11251040 | 0.73 | FFAR4 (0.54) | FFAR4ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL9837024 | 0.72 | KDM4E (0.52) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337261-A | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-06-29 | — | — | US | claimed |
| EP-0045078-A1 | (1,2-Benzisoxazol)phenoxyacetic acids and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-03 | — | — | EP | claimed |
| US-4337261-A | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0045078-A1 | (1,2-Benzisoxazol)phenoxyacetic acids and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-03 | — | — | EP | disclosed |