SCHEMBL11244774

SCHEMBL11244774

CNN=C(NC)N(C)c1ccc(Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
TDP1 Q9NUW8 2/20 0.38
POLB P06746 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.35
RAB9A P51151 1/20 0.35
LMNA P02545 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27562958 0.76 ALDH1A1 (0.36) ALDH1A1TDP1POLBSMN1; SMN2CHRNB2
SCHEMBL5049977 0.72 ROCK2 (0.51) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
Methylamine SCHEMBL11244772 0.69 ALDH1A1 (0.39) ALDH1A1TDP1POLBSMN1; SMN2LMNA
SCHEMBL14868760 0.67 HTR3E (0.37) ALDH1A1TDP1POLBSMN1; SMN2LMNA
SCHEMBL12550518 0.66 POLB (0.50) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
SCHEMBL14853482 0.66 ALDH1A1 (0.50) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
SCHEMBL11722801 0.66 ALDH1A1 (0.38) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
SCHEMBL11815637 0.66 L3MBTL1 (0.49) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
SCHEMBL1114948 0.66 DRD4 (0.48) ALDH1A1TDP1POLBSMN1; SMN2RAB9A
SCHEMBL2095575 0.65 ALDH1A1 (0.48) ALDH1A1TDP1POLBSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326074-A ANTIDIARRHEA AGENTS WILLIAM H. RORER, INC. (US) 1982-04-20 US disclosed
US-4115564-A Treatment of diarrhea with amidinoureas WILLIAM H. RORER, INC. (US) 1978-09-19 US disclosed
US-4025652-A ANTIDIARRHEA AGENTS WILLIAM H. RORER, INC. (US) 1977-05-24 US disclosed