Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.71 |
| ▸ | ALPG | P10696 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.53 |
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162554 | 0.81 | AKR1B1 (0.62) | AKR1B1ALPGKDM4EALDH1A1HPGD | |
| SCHEMBL11007275 | 0.81 | AKR1B1 (0.82) | AKR1B1ALPGKDM4EALDH1A1HPGD | |
| SCHEMBL11005221 | 0.80 | AKR1B1 (0.68) | AKR1B1ALPGKDM4EALDH1A1HPGD | |
| SCHEMBL11009173 | 0.80 | ALPG (0.71) | AKR1B1ALPGKDM4EALDH1A1HPGD | |
| SCHEMBL9459767 | 0.79 | AKR1B1 (0.53) | AKR1B1ALPGKDM4EALDH1A1HPGD | |
| SCHEMBL11267010 | 0.78 | CTDSP1 (0.55) | AKR1B1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL28351868 | 0.78 | KDM4E (0.61) | AKR1B1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL28883171 | 0.78 | KDM4E (0.61) | AKR1B1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL28678221 | 0.78 | KDM4E (0.61) | AKR1B1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL28352180 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4104389-A | Antiallergic pyrido[2,1-b]quinazolin-ones | WARNER-LAMBERT COMPANY (US) | 1978-08-01 | — | — | US | claimed |
| US-4332802-A | 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it | BOEHRINGER INGELHEIM KG (DE) | 1982-06-01 | — | — | US | disclosed |
| US-4104389-A | Antiallergic pyrido[2,1-b]quinazolin-ones | WARNER-LAMBERT COMPANY (US) | 1978-08-01 | — | — | US | disclosed |
| US-4033961-A | ANTIALLERGENS | WARNER-LAMBERT COMPANY (US) | 1977-07-05 | — | — | US | disclosed |