SCHEMBL11246263

SCHEMBL11246263

Nc1ccc(N)c2sncc12

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.33
AXL P30530 1/20 0.32
EP300 Q09472 1/20 0.32
KAT2B Q92831 1/20 0.32
KAT8 Q9H7Z6 1/20 0.32
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6721158 0.83 EP300 (0.44) EP300KAT2BKAT8CYP3A4HSD17B10
SCHEMBL5448026 0.83 GAA (0.38) ALDH1A1CYP3A4TSHR
SCHEMBL11470037 0.78 IDO1 (0.47) EP300KAT8ALDH1A1CYP3A4TSHR
SCHEMBL8976268 0.68 ALDH1A1 (0.44) TDO2ALDH1A1CYP3A4HPGDTSHR
SCHEMBL5439074 0.68 CYP3A4 (0.39) TDO2ALDH1A1CYP3A4HPGDTSHR
SCHEMBL9615205 0.67 TDO2 (0.33) TDO2HSD17B10
SCHEMBL5157339 0.66
SCHEMBL6127891 0.62 CYP1A2 (0.36)
SCHEMBL17339909 0.57
SCHEMBL19590679 0.57

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0011188-B1 PROCESS FOR PREPARING CYANOARYL ETHERS AND CYANOARYL THIOETHERS BASF Aktiengesellschaft (DE) 1982-04-28 EP disclosed
EP-0011188-A2 Process for preparing cyanoaryl ethers and cyanoaryl thioethers BASF Aktiengesellschaft (DE) 1980-05-28 EP disclosed