Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 4/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.32 |
| ▸ | MYLK | Q15746 | 2/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260097 | 0.76 | PRMT6 (0.52) | — | |
| SCHEMBL11248627 | 0.74 | KDM4E (0.41) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11260053 | 0.73 | KDM4E (0.41) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11248268 | 0.70 | GSR (0.43) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11256940 | 0.69 | GLA (0.43) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11254687 | 0.66 | PRMT6 (0.55) | APEX1 | |
| SCHEMBL11245023 | 0.66 | TUBB4A (0.32) | — | |
| SCHEMBL183000 | 0.64 | KDM4E (0.37) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL23656263 | 0.63 | LMNA (0.39) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL10955573 | 0.63 | ACHE (0.36) | TDP1KDM4EPOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001699-B1 | DERIVATIVES OF FURYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1982-02-24 | — | — | EP | disclosed |
| US-4288443-A | HISTAMINE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1981-09-08 | — | — | US | disclosed |