Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243330 | 0.85 | SLC22A12 (0.45) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL11246422 | 0.84 | KDM4E (0.44) | CA2CAMK2AKDM4EHPGDALDH1A1 | |
| SCHEMBL11244551 | 0.84 | KDM4E (0.44) | CA2KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL11237206 | 0.84 | KDM4E (0.47) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL11240017 | 0.84 | KEAP1 (0.51) | CA2KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL11232390 | 0.83 | AKR1B1 (0.53) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| Methane SCHEMBL11235653 | 0.82 | KEAP1 (0.50) | CA2KDM4EHPGDALDH1A1MAPT | |
| Methane SCHEMBL11248449 | 0.81 | AKR1B1 (0.51) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL11253323 | 0.81 | CYP1A2 (0.47) | CA2KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL11246657 | 0.80 | AKR1C2 (0.58) | KDM4EALDH1A1MAPTHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |