Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232390 | 0.98 | AKR1B1 (0.53) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL26312266 | 0.91 | AKR1B1 (0.60) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL11246405 | 0.82 | BCL2L1 (0.50) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| Methane SCHEMBL11235653 | 0.82 | KEAP1 (0.50) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL11236099 | 0.82 | CYP1A2 (0.51) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL14299543 | 0.81 | AKR1B1 (0.56) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL11246646 | 0.81 | CA2 (0.49) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL11243330 | 0.81 | SLC22A12 (0.45) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL31113417 | 0.81 | AKR1B1 (0.56) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL11242088 | 0.81 | BCKDK (0.51) | AKR1B1KDM4EHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |