Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246405 | 0.92 | BCL2L1 (0.50) | SLC22A12KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11237206 | 0.87 | KDM4E (0.47) | SLC22A12KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11246646 | 0.85 | CA2 (0.49) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL11253323 | 0.84 | CYP1A2 (0.47) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL11244551 | 0.84 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL11240017 | 0.84 | KEAP1 (0.51) | SLC22A12KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11246422 | 0.84 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL11243026 | 0.83 | KDM4E (0.41) | SLC22A12KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11246657 | 0.83 | AKR1C2 (0.58) | KDM4EMAPTALDH1A1HSD17B10GAA | |
| SCHEMBL11240004 | 0.83 | KDM4E (0.44) | SLC22A12KDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |