Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 8/20 | 0.48 |
| ▸ | QDPR | P09417 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21361657 | 0.93 | SIGMAR1 (0.52) | SIGMAR1HTR2CQDPRHRH3KDM4E | |
| SCHEMBL9212418 | 0.89 | SIGMAR1 (0.39) | SIGMAR1HTR2CQDPRHRH3 | |
| SCHEMBL296554 | 0.78 | TYMP (0.42) | ALDH1A1 | |
| SCHEMBL918640 | 0.76 | TYMP (0.34) | SIGMAR1HTR2CQDPR | |
| SCHEMBL15274975 | 0.75 | QDPR (0.48) | SIGMAR1HTR2CQDPR | |
| SCHEMBL3233362 | 0.75 | TYMP (0.41) | ALDH1A1 | |
| SCHEMBL18244171 | 0.75 | TYMP (0.41) | ALDH1A1 | |
| SCHEMBL2105114 | 0.75 | TYMP (0.41) | ALDH1A1 | |
| SCHEMBL21057468 | 0.75 | TYMP (0.41) | ALDH1A1 | |
| SCHEMBL3502363 | 0.75 | TYMP (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449485-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449485-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20080146572-A1 | N-SULFONYLUREA APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146572-A1 | N-SULFONYLUREA APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | US | disclosed |
| US-7358251-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358251-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES (US) | 2008-04-15 | — | — | US | disclosed |
| EP-0012471-B1 | AZABICYCLOHEXENE DERIVATIVES, A PROCESS FOR PREPARING THEM, POLLEN-SUPPRESSING COMPOSITIONS, A METHOD OF PRODUCING F1 HYBRID SEED, AND SEED THUS PRODUCED | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-10-06 | — | — | EP | disclosed |
| EP-0012471-A1 | Azabicyclohexene derivatives, a process for preparing them, pollen-suppressing compositions, a method of producing F1 hybrid seed, and seed thus produced | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146572-A1 | N-SULFONYLUREA APOPTOSIS PROMOTERS | BAX, BCL2, BAD | SIGMAR1 2873/4885HTR2C 3746/4885QDPR 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.