Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 8/20 | 0.50 |
| ▸ | QDPR | P09417 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246723 | 0.93 | SIGMAR1 (0.50) | SIGMAR1HTR2CQDPRHRH3KDM4E | |
| SCHEMBL9212418 | 0.83 | SIGMAR1 (0.39) | SIGMAR1HTR2CQDPRHRH3 | |
| SCHEMBL918640 | 0.82 | TYMP (0.34) | SIGMAR1HTR2CQDPR | |
| SCHEMBL604266 | 0.77 | TYMP (0.40) | HRH3ALDH1A1 | |
| SCHEMBL15048839 | 0.77 | TYMP (0.40) | HRH3ALDH1A1 | |
| SCHEMBL8015147 | 0.73 | SIGMAR1 (0.52) | SIGMAR1HTR2CQDPRHRH3KDM4E | |
| SCHEMBL3343472 | 0.72 | — | — | |
| SCHEMBL28649782 | 0.72 | — | — | |
| SCHEMBL1109730 | 0.72 | TYMP (0.41) | ALDH1A1 | |
| SCHEMBL23074510 | 0.71 | SIGMAR1 (0.46) | SIGMAR1HTR2CQDPRHRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765447-B1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |