Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | NEK4 | P51957 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11484789 | 0.82 | EGFR (0.46) | EGFRABCG2KDRAURKBLMNA | |
| SCHEMBL11495349 | 0.80 | EGFR (0.53) | KRASEGFRABCG2DYRK3MAP4K4 | |
| SCHEMBL11249317 | 0.72 | NR2F2 (0.59) | KRASEGFRABCG2DYRK3MAP4K4 | |
| SCHEMBL11240075 | 0.65 | EGFR (0.53) | KRASEGFRABCG2DYRK3MAP4K4 | |
| SCHEMBL11251547 | 0.65 | GALR3 (0.51) | KRASEGFRABCG2DYRK3MAP4K4 | |
| SCHEMBL11254363 | 0.64 | EGFR (0.52) | EGFRABCG2DYRK3MAP4K4PDGFRA | |
| SCHEMBL11245481 | 0.62 | APP (0.53) | CLK4SMN1; SMN2POLBKMT2AMAPK1 | |
| SCHEMBL11246532 | 0.62 | EGFR (0.51) | EGFRABCG2DYRK3MAP4K4PDGFRA | |
| SCHEMBL11250518 | 0.62 | DRD2 (0.53) | SMN1; SMN2HTTPOLBKMT2ATP53 | |
| SCHEMBL11246446 | 0.61 | GBA1 (0.54) | SMN1; SMN2NPC1RAB9AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |