Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | NEK4 | P51957 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256846 | 0.87 | NR2F2 (0.59) | EGFRHTTNR2F2GALR3KDR | |
| SCHEMBL11261278 | 0.87 | EGFR (0.52) | EGFRHTTNR2F2GALR3KDR | |
| SCHEMBL11250025 | 0.86 | NPC1 (0.52) | EGFRHTTHIF1ANR2F2GALR3 | |
| SCHEMBL11246532 | 0.86 | EGFR (0.51) | EGFRHTTHIF1ANR2F2GALR3 | |
| SCHEMBL11243265 | 0.84 | HTT (0.55) | EGFRHTTNR2F2GALR3GBA1 | |
| SCHEMBL11495349 | 0.81 | EGFR (0.53) | EGFRHTTHIF1ANR2F2GALR3 | |
| SCHEMBL11255628 | 0.81 | GBA1 (0.56) | EGFRHTTNR2F2GALR3KDR | |
| SCHEMBL11248882 | 0.81 | EGFR (0.52) | EGFRHTTNR2F2GALR3KDR | |
| SCHEMBL11246634 | 0.80 | SMN1; SMN2 (0.51) | EGFRHTTNR2F2GALR3KDR | |
| SCHEMBL11103433 | 0.80 | ADRB2 (0.44) | SMN1; SMN2KMT2AADRB2ADRB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |