Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | NEK4 | P51957 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11249317 | 0.87 | NR2F2 (0.59) | EGFRHTTGALR3NR2F2KDR | |
| SCHEMBL11240075 | 0.81 | EGFR (0.53) | EGFRHTTHIF1AGALR3NR2F2 | |
| SCHEMBL11246968 | 0.80 | KRAS (0.40) | EGFRHTTHIF1AGALR3NR2F2 | |
| SCHEMBL11254363 | 0.80 | EGFR (0.52) | EGFRHTTHIF1AGALR3NR2F2 | |
| SCHEMBL11246532 | 0.77 | EGFR (0.51) | EGFRHTTHIF1AGALR3NR2F2 | |
| SCHEMBL11251547 | 0.76 | GALR3 (0.51) | EGFRHTTGALR3NR2F2KDR | |
| SCHEMBL11249694 | 0.73 | LDHA (0.64) | EGFRHTTHIF1ANR2F2KDR | |
| SCHEMBL11255679 | 0.72 | LMNA (0.59) | EGFRHTTHIF1ANR2F2KDR | |
| SCHEMBL11255375 | 0.71 | LMNA (0.60) | EGFRHTTHIF1ANR2F2KDR | |
| SCHEMBL15889088 | 0.71 | GALR3 (0.71) | EGFRHTTGALR3NR2F2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |