Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.67 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | EBP | Q15125 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244026 | 0.99 | OPRD1 (0.69) | OPRD1OPRK1OPRM1SIGMAR1DRD3 | |
| SCHEMBL11246705 | 0.91 | OPRD1 (0.65) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| SCHEMBL11178963 | 0.88 | OPRM1 (0.70) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| SCHEMBL11178955 | 0.88 | OPRM1 (0.70) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| SCHEMBL11194601 | 0.87 | OPRM1 (0.69) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| SCHEMBL11194604 | 0.87 | OPRM1 (0.69) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| Bromide SCHEMBL11267877 | 0.86 | OPRM1 (0.66) | OPRD1OPRK1OPRM1 | |
| Bromide SCHEMBL11251114 | 0.86 | SLC6A4 (0.53) | OPRD1OPRK1OPRM1DRD3DRD4 | |
| SCHEMBL11254924 | 0.84 | OPRM1 (0.67) | OPRD1OPRK1OPRM1 | |
| SCHEMBL11254787 | 0.84 | OPRK1 (0.68) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337341-A | 4a-Aryl-octahydro-1H-2-pyrindines | ELI LILLY AND COMPANY (US) | 1982-06-29 | — | — | US | disclosed |